iCOGS Complete Summary Results

Text files are available with results based on genome-wide association analysis, using the iCOGS dataset and additional GWAS. We provide summary association statistics for overall, ER-positive and ER-negative breast cancer, and for overall and subtype-specific survival. Results are provided for SNPs genotyped on the iCOGS array, after quality control, and imputed results based on the 1000 Genomes Project Phase 1 reference panel. Separate analyses and imputations were performed for samples of European, Asian and African ethnicities.

References

The risk analyses are described in Michailidou K et al (2013) “Large-scale genotyping identifies 41 new loci associated with breast cancer risk” and Michailidou K et al (2015) “Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer”. The survival analysis are described in Guo Q et al (2015) “Identification of novel genetic markers of breast cancer survival”.

Acknowledgements

You are free to use this resource in a publication. Please acknowledge the following:

Funding for BCAC and iCOGS came from: Cancer Research UK [grant numbers C1287/A16563, C1287/A10118, C1287/A10710, C12292/A11174, C1281/A12014, C5047/A8384, C5047/A15007, C5047/A10692, C8197/A16565], the European Union’s Horizon 2020 Research and Innovation Programme (grant numbers 634935 and 633784 for BRIDGES and B-CAST respectively), the European Community’s Seventh Framework Programme under grant agreement n° 223175 [HEALTHF2-2009-223175] (COGS), the National Institutes of Health [CA128978] and Post-Cancer GWAS initiative [1U19 CA148537, 1U19 CA148065-01 (DRIVE) and 1U19 CA148112 - the GAME-ON initiative], the Department of Defence [W81XWH-10-1-0341], and the Canadian Institutes of Health Research CIHR) for the CIHR Team in Familial Risks of Breast Cancer [grant PSR-SIIRI-701]. All studies and funders as listed in Michailidou K et al (2013 and 2015) and in Guo Q et al (2015) are acknowledged for their contributions

Disclaimer Use of Survival Estimates

The summary estimates for the association between germline variants and survival are based on iCOGS BCAC and GWAS data as published in: Guo Q and Schmidt MK et al JCNI 2015 (PMCID: PMC4555642). Please refer to this paper when using these survival summary results. The estimates were based on follow-up data available at the time of the analyses (BCAC version 2014) and on imputed genotype data using the 1000 Genomes Project data set (March 2012) as a reference. Please realise that the data online are not the most recent and estimates may have changed in analyses using updated follow-up data and/or another reference.

Terms of Use

The sample size and precision of the data presented should preclude identification of any individual subject. However, in downloading these data, you undertake not to attempt to identify individual subjects and not to repost these data to a third party website.

Description of field names in results files.

I agree to the terms of use: